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KMID : 0857020040190010195
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Kosin Medical Journal
2004 Volume.19 No. 1 p.195 ~ p.200
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The clinical characteristics, survival rate and prognostic factors of pathologic stage T1 renal cell carcinoma
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Moon Il
Kim Taek-Sang
Rhew Hyun-Yul
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Abstract
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Background : To assess the effect of renal cell carcinoma(RCC) subtype, tumor size, and Fuhrman grade on clinical outcome in patients with pathologic T1 RCC treated with radical nephrectomy.
Methods : Between 1985 and 1998, 58 patients underwent radical nephrectomy for pT1 RCC. Tumors were subtyped and graded. Univariate and multivariate Cox proportional hazards models were fitted to assess the features associated with cancer-specific survival(CSS). We investigated a range of tumor sizes of clear cell RCC in which a transition occurred from low to high risk.
Results: The mean follow-up was 8.6 years among the patients alive at latest follow-up. At 10 years, the CSS for clear cell RCC(n=48) were 93.75% : for papillary RCC(n=6). they were 100% and for chromophobe RCC (n=4) were 71.4%. The differences in CSS(p=0.32) between clear cell FCC and the other subtypes were not statistically significant. The tumor sizes and nuclear grade had not a statistical significancy as prognostic factor for pT1 RCC
Conclusion: In this study, the survival rates of patients with pathologic T1 RCC treated with radical nephrectomy were favorable. But because of the small number of patients, the collecting of larger data through the randomized multicenter study are required to identify the prognostic factors of pT1 RCC.
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KEYWORD
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pT1 Renal cell carcinoma, Prognostic factors, Survival rate
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